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Gene M Dubowchik Selected Research

Calcitonin Gene-Related Peptide

1/2021Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.
1/2020Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success.
2/2016Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines.
6/2013Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.
12/2012Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine.
4/2012Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine.
7/2009Carbamates as potent calcitonin gene-related peptide antagonists with improved solution stability.
8/2008Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure.

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Gene M Dubowchik Research Topics

Disease

11Migraine Disorders (Migraine)
01/2021 - 08/2008
9Neoplasms (Cancer)
01/2023 - 01/2002
4Alzheimer Disease (Alzheimer's Disease)
01/2023 - 05/2015
2Mood Disorders (Mood Disorder)
01/2023 - 02/2016
1Type 2 Diabetes Mellitus (MODY)
01/2023
1Pain (Aches)
11/2019
1Hematologic Neoplasms (Hematological Malignancy)
01/2018
1Breast Neoplasms (Breast Cancer)
01/2018
1Bipolar Disorder (Manic Depressive Psychosis)
05/2015
1Stroke (Strokes)
05/2015
1Neurodegenerative Diseases (Neurodegenerative Disease)
05/2015
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
05/2003
1Melanoma (Melanoma, Malignant)
02/2003
1Carcinoma (Carcinomatosis)
07/2002

Drug/Important Bio-Agent (IBA)

8Calcitonin Gene-Related PeptideIBA
01/2021 - 08/2008
8Calcitonin Gene-Related Peptide Receptor AntagonistsIBA
01/2021 - 04/2012
4Glycogen Synthase Kinase 3IBA
01/2023 - 05/2015
4Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)IBA
01/2021 - 08/2008
4Immunoconjugates (Immunoconjugate)IBA
01/2018 - 01/2002
4AntigensIBA
05/2003 - 06/2002
2tau Proteins (tau Protein)IBA
01/2023 - 01/2023
2piperidineIBA
06/2013 - 12/2012
24- (8- fluoro- 2- oxo- 1,2- dihydroquinazolin- 3(4H)- yl)- N- (3- (7- methyl- 1H- indazol- 5- yl)- 1- oxo- 1- (4- (piperidin- 1- yl)piperidin- 1- yl)propan- 2- yl)piperidine- 1- carboxamideIBA
04/2012 - 08/2008
2Monoclonal AntibodiesIBA
05/2003 - 07/2002
2Doxorubicin (Adriamycin)FDA LinkGeneric
09/2002 - 07/2002
1rimegepant sulfateIBA
11/2019
1Ado-Trastuzumab EmtansineIBA
01/2018
1Brentuximab VedotinIBA
01/2018
1NeuropeptidesIBA
02/2016
1Glycogen Synthase (Synthase I)IBA
05/2015
1Tryptamines (Triptans)IBA
06/2013
1N- (3- (7- methyl- 1H- indazol- 5- yl)- 1- (4- (1- methylpiperidin- 4- yl)- 1- oxopropan- 2- yl))- 4- (2- oxo- 1,2- dihydroquinolin- 3- yl)piperidine- 1- carboxamideIBA
06/2013
1AmidesIBA
04/2012
1pyridineIBA
04/2012
1BMS-846372IBA
04/2012
1AntibodiesIBA
05/2003
1CalicheamicinsIBA
05/2003
1Gemtuzumab (Mylotarg)FDA Link
05/2003
1ProdrugsIBA
02/2003
1Proteins (Proteins, Gene)FDA Link
02/2003
1AcidsIBA
02/2003
1Peptides (Polypeptides)IBA
09/2002
1DipeptidesIBA
07/2002
1serum P-component (CIt)IBA
07/2002
1Cathepsin BIBA
01/2002
1CamptothecinIBA
01/2002

Therapy/Procedure

4Therapeutics
01/2020 - 05/2003